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Ranirestat  ≥98%

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包装规格：5mg 10mg 50mg in glass bottle
溶解性：溶于DMSO(≥50mg/ml)
产品描述：一种有效的，口服活性的醛糖还原酶(AR)抑制剂，对大鼠晶状体AR和重组人AR的IC50分别为11nM和15nM，对于重组人AR的Ki为0.38nM。Ranirestat可用于糖尿病感觉运动性多发性神经病的研究，并且对糖尿病视网膜具有神经保护作用。Ranirestat, also known as AS-3201; SX-3201, is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. Aldose reductase is an enzyme that catalyzes one of the steps in sorbitol (polyol) pathway which is responsible for formation of fructose from glucose. Aldose reductase activity is increased, parallel to glucose blood levels, in tissues that are not insulin sensitive, including lenses, peripheral nerves and renal glomeruli. Sorbitol does not diffuse through cell membranes easily and therefore accumulates in these tissues, causing osmotic damage, leading to retinopathy and neuropathy.
保存条件：-20℃

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