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M77976  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(250mg/ml超声)
产品描述：一种特异性的，ATP竞争性的丙酮酸脱氢酶激酶PDK4抑制剂，其作用的IC50值为648μM。M77976有用于肥胖症和糖尿病研究的潜力。 M77976 is a PDK4 inhibitor (human pyruvate dehydrogenase kinase 4). M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid. M77976 binding also leads to a large domain rearrangement that further expands the active-site cleft of PDK4 compared with the ADP- and AMPPNP-bound forms. Biochemical analyses revealed that M77976 inhibits PDK4 with increased potency compared with the previously characterized PDK inhibitor radicicol.
保存条件：-20℃

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