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Ilaprazole 促销  ≥98%

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包装规格：100mg 250mg 1g 5g in glass bottle
溶解性：溶于DMSO(≥35mg/ml)
产品描述：基本信息 产品编号： I10361  产品名称： Ilaprazole CAS: 172152-36-2   储存条件 粉末 -20℃ 四年     分子式： C19H18N4O2S 溶于液体 -80℃ 6个月 分子量： 366.44 -20℃ 1个月 化学名：  2-[(4-METHOXY-3-METHYL-PYRIDIN-2-YL)METHYLSULFINYL]-5-PYRROL-1-YL-3H-BENZOIMIDAZOLE Solubility (25°C)：   体外:   DMSO 73mg/mL (199.21mM) Ethanol 14mg/mL (38.2mM) Water Insoluble 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7290mL 13.6448mL 27.2896mL 5mM 0.5458mL 2.7290mL 5.4579mL 10mM 0.2729mL 1.3645mL 2.7290mL   生物活性 产品描述 一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为6μM。Ilaprazole用于胃溃疡的研究。Ilaprazole也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。 靶点 IC50:6.0μM (H+/K+-ATPase) 体外研究 On cumulation of 14C-aminopyrine in histamine stimulated parietal cells,the IC50 of Ilaprazole (IY-81149) sodium is 9nM. 体内研究 Ilaprazole (3-30mg/kg;i.d.) dose-dependently inhibits gastric acid secretion.In anesthetized rats,Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion.In the case of i.v.injection,the ED50 of Ilaprazole and omeprazole is 1.2 and 1.4mg/kg and in the case of i.d.administration,the ED50 of Ilaprazole and omeprazole is 3.9 and 4.1mg/kg,respectively.Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion.Its ED50 is 2.1mg/kg and that of Omeprazole is 3.5mg/kg with i.d.administration.In the case of i.v.injection,Ilaprazole is equipotent to Omeprazole.Ilaprazole also inhibits gastric acid secretion strongly in fistular rats.The ED50 of Ilaprazole administered intraduodenally is 0.43mg/kg and that of Omeprazole is 0.68mg/kg. Animal Model: Male SD rat (after pylorus ligation) Dosage: 3,10,30mg/kg Administration: Intraduodenally Result: The acid output and volume significantly inhibited by about 60% and 46% at 3mg/kg were s,respectively.At 30mg/kg,it showed 93% and 73% inhibition on acid output and volume,respectively.
保存条件：-20℃

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