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VER-246608  ≥98%

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包装规格：1mg 5mg 10mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(100mg/ml超声)
产品描述：一种有效的，ATP竞争性的丙酮酸脱氢酶激酶(PDK)抑制剂。 VER-246608 is a pan-inhibitor of pyruvate dehydrogenase kinase (PDHK; IC50s = 35, 84, 40, and 91 nM for PDHK1, -2, -3, and -4, respectively). It is selective for PDHKs over heat shock protein 90 (Hsp90; IC50 = >100 µM), as well as a panel of 97 kinases at 10 µM. VER-246608 (10 and 20 µM) decreases the production of L-lactate, a marker of glycolytic activity, in PC3 cells cultured in D-glucose- and L-glutamine-depleted media. It reduces the growth of, and induces cell cycle arrest at the G1 phase in, serum-starved PC3 cells when used at a concentration of 20 µM.
保存条件：-20℃

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