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Sodium ilaprazole  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(40mg/ml 超声)
产品描述：基本信息 产品编号： I10362 产品名称： Sodium ilaprazole CAS: 172152-50-0   储存条件 粉末 -20℃ 四年 分子式： C19H17N4NaO2S 溶于液体 -80℃(避光) 6个月 分子量： 388.42 -20℃(避光) 1个月 化学名：  sodium;2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5-pyrrol-1-ylbenzimidazol-3-ide Solubility (25°C)：   体外:   DMSO 78mg/mL (200.81mM) Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.5745mL 12.8727mL 25.7453mL 5mM 0.5149mL 2.5745mL 5.1491mL 10mM 0.2575mL 1.2873mL 2.5745mL   生物活性 产品描述 一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为6μM。Ilaprazolesodium用于胃溃疡的研究。Ilaprazolesodium也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。 靶点 Proton Pump TOPK 体外研究 On cumulation of 14C-aminopyrine in histamine stimulated parietal cells,the IC50 of Ilaprazole (IY-81149) sodium is 9nM. 体内研究 Ilaprazole sodium (3-30mg/kg;i.d.) dose-dependently inhibits gastric acid secretion.In anesthetized rats,Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v.injection,the ED50 of Ilaprazole sodium and Omeprazole is 1.2 and 1.4mg/kg and in the case of i.d.administration,the ED50 of Ilaprazole sodium and omeprazole is 3.9 and 4.1mg/kg,respectively.Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion.Its ED50 is 2.1mg/kg and that of Omeprazole was 3.5mg/kg with i.d.administration. In the case of i.v.injection,Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats.The ED50 of Ilaprazole sodium administered intraduodenally is 0.43mg/kg and that of omeprazole Is 0.68mg/kg. Animal Model: Male SD rat (after pylorus ligation) Dosage: 3,10,30mg/kg Administration: Intraduodenally Result: The acid output and volume significantly inhibited by about 60% and 46% at 3mg/kg were s,respectively.At 30mg/kg,it showed 93% and 73% inhibition on acid output and volume,respectively.
保存条件：-20℃

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