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Phenytoin  ≥98%

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包装规格：25g 100g in poly bottle
溶解性：溶于DMSO(100mg/ml 超声)
产品描述：基本信息 产品编号： P11297 产品名称： Phenytoin CAS: 57-41-0   储存条件 粉末 -20℃ 四年     分子式： C15H12N2O2 溶于液体 -80℃ 6个月 分子量： 252.27 -20℃ 1个月 化学名：  Phenytoin solution,1.0mg/mL in methanol,ampule of 1mL,certified reference material Solubility (25°C)：   体外:   DMSO 50mg/mL (198.2mM) Ethanol 13mg/mL (51.53mM) Water Insoluble 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.9640mL 19.8200mL 39.6401mL 5mM 0.7928mL 3.9640mL 7.9280mL 10mM 0.3964mL 1.9820mL 3.9640mL   生物活性 产品描述 一种有效的电压门控Na+通道(VGSCs)阻滞剂。Phenytoin具有抗癫痫活性，也可减少小鼠乳腺肿瘤的生长和转移。 靶点 Sodium Channel Virus Protease   体外研究 Phenytoin is an antiepileptic drug.It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures.Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels.Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials.When neurons are depolarized and the channels transition into the open and inactivated states,greater binding and block occur.The inhibitory potency is strongly use dependent,so that block accumulates with prolonged or repetitive activation,such as occurs during a seizure discharge.The blocking of sodium channels by phenytoin is of slow onset.The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity.Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control.Phenytoin is a class 1b antiarrhythmic. 体内研究 Phenytoin (5,5-Diphenylhydantoin;60mg/kg;daily;28 days) reduces tumour growth in six week-old female Rag2-/-Il2rg-/-mice with MDA-MB-231 cells.
保存条件：-20℃

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