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BRD7389  ≥98%

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： B11309 产品名称： BRD7389 CAS: 376382-11-5   储存条件 粉末 -20℃ 四年     分子式： C24H18N2O2 溶于液体 -80℃ 六个月 分子量 366.41 -20℃ 一个月 化学名：  2-hydroxy-1-(phenethylamino)-7H-naphtho[1,2,3-de]quinolin-7-one   生物活性 产品描述 一种特异性的RSK家族激酶抑制剂,可以诱导胰腺α细胞中胰岛素表达。 靶点 RSK1 1.5μM(IC50) RSK2 2.4μM(IC50) RSK3 1.2μM(IC50) CDK5/p35 6.5μM(IC50) DRAK1 2.8μM(IC50) FLT3 3.5μM(IC50) PIM1 3.7μM(IC50) PKG1α 6.5μM(IC50) SGK 13.8μM(IC50)   体外研究 BRD7389 (0.425-6.8μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dosedependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85μM. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line. BRD7389 also increases β-cell-specific gene expression in primary human islet cells. BRD7389 (1μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation RT-PCR Cell Line: Mouse α-cell line Concentration: 0.425, 0.85, 1.7, 3.4, 6.8μM Incubation Time: 3 days and 5 days Result: Up-regulated expression of Pdx1. Cell Proliferation Assay Cell Line: SNU-407 colon cancer cell Concentration: 1μM Incubation Time: Added 30 min prior to Carbachol treatment (48 h) Result: Almost completely blocked Carbachol (1mM)-stimulated cell proliferation.
保存条件：-20℃

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