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TDN345  

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包装规格：1mg 5mg in glass bottle
产品描述：基本信息 产品编号： T11119 产品名称： TDN345 CAS: 134069-68-4   储存条件 粉末 -20℃ 四年 分子式： C28H34F2N2O2 溶于液体 -80℃ 一年 分子量： 468.58     化学名：  1-Oxa-3,8-diazaspiro(4.5)decan-2-one,8-(4,4-bis(4-fluorophenyl)butyl)-3-(1,1-dimethylethyl)-4-methylene- Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种Ca2+拮抗剂，主要用于血管和老年痴呆疾病，例如阿尔茨海默症的研究。 靶点 Calcium Channel   体外研究 TDN-345 (10μM) significantly increases the intracellular NGF content in the time-course study.TDN-345 induces NGF synthesis/secretion at the concentrations of 0.1μM;statistically significant at 1μM.The ED50 is 0.88μM. 体内研究 TDN-345 (0.1-1.0mg/kg,p.o.) dose-dependently decreases the mortality and ischemic neurological deficit score when administered orally twice,60 min before ischemia and 90 min after recirculation.Additionally,TDN-345 (0.2 or 1.0mg/kg,p.o.once daily for 3 weeks after the onset of stroke) decreases the mortality and recurrence of stroke in SHRSP.   推荐实验方法(仅供参考) 动物实验:   Male Mongolian gerbils (50-70g body weight) are anesthetized lightly by ether inhalation.A 1-2 cm midline throat incision provided access to both carotid arteries,which are clamped with microaneurysm clamps immediately after recovery from anesthesia.Sixty minutes before occlusion,TDN-345 (0.3 or 1.0mg/kg suspended in a 5% gum arabic solution or 0.1 or 0.3mg/kg with 1% NaHCO3 suspended in a 5% gum arabic solution) or vehicle is administered orally.After 15 min of bilateral carotid artery occlusion,the clamps are removed.Ninety minutes after reperfusion,TDN-345 or vehicle is again administered orally.The body temperature is maintained at 37℃ during the experimental period using a heating pad.The experiments are performed in nine to 15 animals in each group.Animal survival is observed 8h and 7 days after reperfusion,and neurological signs are evaluated according to the scoring system as an ischemic neurological score for 5h after the ischemic insult from an area under the time-neurological deficit score curve (AUCreperfusion (0-300 min)) (hair roughed up or tremor,obtunded,paucity of move,1;ptosis,seizure,2;head cocked,eyes fixed open,splayed out hind limbs,extreme rotation,circling behavior,rolling seizure,3;coma,6;death,34).Nine to 15 animals are used in each experimental group.
保存条件：-20℃

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