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(2R/S)-6-PNG  

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： P11255  产品名称： (2R/S)-6-PNG CAS: 68682-01-9   储存条件 粉末 -20℃ 四年 分子式： C20H20O5 溶于液体 -80℃ 6个月 分子量： 340.37 -20℃ 1个月 化学名：  5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种T型Ca2+通道(Cav3.2)阻滞剂。(2R/S)-6-PNG抑制小鼠疼痛模型中的神经性异常性疼痛。 靶点 Cav3.2   体外研究 (2R/S)-6-PNG (6-Prenylnaringenin) potently blocks Cav3.2,but exhibits minor effect on high-voltage-activated Ca2+channels and voltage-gated Na+channels in differentiated NG108-15 cells.On the basis of IC50 values,the proportion (Cav3.2/HVA) of the inhibition potency of (2R/S)-6-PNG on Cav3.2 and HVAcurrents is 5.20,and that (Cav3.2/Nav) on Cav3.2 and Nav-currents is 3.54. 体内研究 (2R/S)-6-PNG (6-Prenylnaringenin;10-30mg/kg;i.p.;single dose;15 min before Na2S) significantly reduced the Na2Sinduced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i.col.) administration of Na2S,an H2S donor.(2R/S)-6-PNG (30mg/kg;i.p.) prevents the increased number of phosphorylated ERK-positive cells following i.col.Na2S in laminae I-II,V-VI and X to which the primary afferent neurons project,and the Na2S-induced increase in the phosphorylated ERK-positive cell number.(2R/S)-6-PNG (0.01-1 and 0.1-10nmol/paw;intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p.administration of Oxaliplatin (OHP) a,respectively,in a dose-dependent manner.(2R/S)-6-PNG (20-30mg/kg;i.p.) significantly reverses the PSNL-induced allodynia.(2R/S)-6-PNG (10-20mg/kg;i.p.) significantly reverses the OHP-induced allodynia (5mg/kg;i.p.;single dose).
保存条件：-20℃

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