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(R)-Lisofylline  ≥95%

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： R10353  产品名称： (R)-Lisofylline CAS: 100324-81-0   储存条件 粉末 -20℃ 四年 分子式： C13H20N4O3 溶于液体 -80℃(氮气保存) 6个月 分子量： 280.32 -20℃(氮气保存) 1个月 化学名：  3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种Pentoxifylline代谢产物的(R)-型对映体，具有抗炎特性。一种溶血磷脂酸酰基转移酶(lysophosphatidicacidacyltransferase)抑制剂，IC50为0.6µM，可中断IL-12信号介导的STAT4激活。(R)-Lisofylline可用于1型糖尿病，自身免疫性疾病的研究。 靶点 IC50:0.6µM (Lysophosphatidic acid acyltransferase) STAT4 体外研究 (R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro. 体内研究 (R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells,suppresses IFN-γ production,the onset of diabetes,and macrophage infiltration into islets from NOD mice,as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test.(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling.(R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice.(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs.In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs.(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or Escherichia coli.
保存条件：-20℃

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