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Ro 10-5824 dihydrochloride  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于水（100mg/mL 超声），溶于DMSO（8.33mg/mL 超声）
产品描述：基本信息 产品编号： R10324 产品名称： Ro 10-5824 dihydrochloride CAS: 189744-94-3   储存条件 粉末 -20℃ 四年     分子式： C17H20N4.2HCl 溶于液体 -80℃ 6个月 分子量： 353.29 -20℃ 1个月 化学名：  5-[(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)METHYL]-2-METHYL-4-PYRIMIDINAMINE DIHYDROCHLORIDE Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8305mL 14.1527mL 28.3054mL 5mM 0.5661mL 2.8305mL 5.6611mL 10mM 0.2831mL 1.4153mL 2.8305mL   生物活性 产品描述 一种选择性的 dopamine D4 受体 部分激动剂，Ki 值为 5.2nM。 靶点 Ki:5.2nM (dopamine D4 receptor)   体外研究 RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R,and>1000 fold selectivity for D4 vs human D2,D1,and D5 receptors.RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67nM (n=7) and maximal induction at 36±4% above basal level. 体内研究 Ro 10-5824 (3mg/kg) increases the success rate in the ORD task.At doses of 1 and 3mg/kg,Ro 10-5824 increases baseline gamma band activity in the frontal cortex.Ro 10-5824 has no effect on spontaneous locomotion.RO-10-5824 (10.0mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present,nor does it increase overall transitions in the initial experiment with C57 mice.   推荐实验方法(仅供参考) 动物实验:   In the experiment,39 C57 and 40 DBA mice are tested over a three-day period.On days 1 and 2,mice are placed into the VT for 60 min and locomotor behavior is recorded. On the third day,mice are placed into the VT chamber for 60 min.Following the 60-min period,mice are removed from the chambers and administered 0,1.0,3.0,or 10.0mg/kg of RO-10-5824 (n=9-11 per group).Mice are assigned to drug group pseudo-randomly,with each dose being represented in a cage of four mice.A novel paper cup measuring 9.5 cm in height and 7.5 cm in diameter at the rim is placed upside down in the center of each open field and secured to the floor with tape.Mice are returned to the VT 10 min following injection and tested for an additional 30 min.
保存条件：-20℃

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