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托美丁钠二水  ≥98%

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包装规格：25g in glass bottle
溶解性：溶于H2O（≥100mg/mL）
产品描述：基本信息 产品编号： T11001 产品名称： Tolmetin sodium dihydrate CAS: 64490-92-2   储存条件 粉末 2-8℃ 四年     分子式： C15H18NNaO5 溶于液体 -80℃ 6个月 分子量： 315.30 -20℃ 1个月 化学名：  1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.1716mL 15.8579mL 31.7158mL 5mM 0.6343mL 3.1716mL 6.3432mL 10mM 0.3172mL 1.5858mL 3.1716mL   生物活性 产品描述 一种具有口服活性的，有效的COX抑制剂。 靶点 Human COX-1 0.35μM (IC50) Human COX-2 0.82μM (IC50)   体外研究 Tolmetin sodium dihydrate (0.25mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25,0.5,0.75,1mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.Tolmetin sodium dihydrate (0.001-100μM) shows anticancer activity againts HT-29 colon cancer cell line in a dosedependent manner.Tolmetin sodium dihydrate (0-100μM) shows no effect on osteoblast growth. 体内研究 Tolmetin sodium dihydrate (30,100mg/kg;gavage;single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4h after the single dose,while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200g.Tolmetin causes gastric lesions in 100mg/kg.Tolmetin sodium dihydrate (5mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.   推荐实验方法(仅供参考) 动物实验:   Rats After 2 weeks of acclimatization,rats are randomized to different groups and given the non-selective COX inhibitors,amtolmetin guacyl (AMG) (50 and 150mg/kg) and Tolmetin (30 and 100mg/kg) as well as the selective COX-2 inhibitor,celecoxib (CXIB;20 and 60mg/kg).The compounds are suspended in 1% carboxymethylcellulose (CMC) immediately before use and administered by gavage in a 10-mL/kg volume.Control groups receive CMC in the same volume.Rats from each group are divided into 3 subgroups,consisting each of at least 10 animals.Subgroups are dosed either with a single dose (acute treatment group) or twice daily for 3 and 14 days (chronic treatment groups).To ensure that all groups are dosed for the same period of time,those receiving less than 14 days of NSAIDs are given CMC until they are due to start the assigned treatment.Rats are killed by cervical dislocation 4h after the last administration.Stomachs are immediately removed,opened along the lesser curvature and gently rinsed.
保存条件：2-8℃

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