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维拉必利  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥100mg/mL）
产品描述：基本信息 产品编号：V10109 产品名称：Veralipride CAS: 66644-81-3   储存条件 粉末 -20℃ 四年     分子式： C17H25N3O5S 溶于液体 -80℃ 六个月 分子量： 383.46 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.6078mL 13.0392mL 26.0783mL 5mM 0.5216mL 2.6078mL 5.2157mL 10mM 0.2608mL 1.3039mL 2.6078mL   生物活性 产品描述 是 D2 受体的拮抗剂。 它是一种替代抗抑郁药研究绝经期症状的化合物。 靶点/IC50 Dopamine Receptor   体外研究 Veralipride administration (100mg/day for 30 days) induces a significant reduction in vasomotor symptoms and is more effective than placebo.Treatment is followed by the expected increase in plasma prolactin levels and by a significant decrease in mean plasma LH.A significant reduction is observed in objectively recorded hot flushes after Veralipride treatment.Veralipride is well absorbed when administered orally,achieving maximal concentrations at 2.5 hours.It is poorly metabolized and is eliminated in the urine and feces.After oral administration,the half-life is 4 hours,and 44% is excreted without any changes in urine in the first 120 hours.A total of 57 adverse events are registered during the 386-month treatment.For the 20×10 dosing schedule,the highest incidence is observed for anxiety (2.2%), drowsiness,and weakness (1.5%);for the 5×2 dosing schedule,the highest incidence is observed for drowsiness (5.3%) and headache (2.6%).Veralipride is known to cause extrapiramidal signs such as bucco-facial or limb dyskinesia.Veralipride may cause reversible parkinsonism.
保存条件：-20℃

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