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丙谷胺  ≥98%

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包装规格：1g in glass bottle
溶解性：溶于DMSO（≥65mg/mL 超声）
产品描述：基本信息 产品编号： P11004  产品名称： Proglumide CAS: 6620-60-6   储存条件 粉末 -20℃ 四年     分子式： C18H26N2O4 溶于液体 -80℃ 6个月 分子量： 334.41 -20℃ 1个月 化学名：  4-(N,N-dipropylcarbamoyl)-4-(phenylcarbonylamino)butanoic acid Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9903mL 14.9517mL 29.9034mL 5mM 0.5981mL 2.9903mL 5.9807mL 10mM 0.2990mL 1.4952mL 2.9903mL   生物活性 产品描述 一种非肽和口服活性胆囊收缩素 (CCK)-A/B 受体拮抗剂。Proglumide 选择性阻断 CCK 在中枢神经系统中的作用。Proglumide 具有抑制胃分泌和保护胃十二指肠粘膜的能力，还具有抗癫痫和抗氧化活性。 靶点 Cholecystokinin (CCK)-A/B receptors   体外研究 In an in vitro study,Proglumide at concentrations between 0.3-10mM inhibits CCK-stimulated amylase release dosedependently,while Proglumide does not influence the basal amylase release at concentrations between 0-3mM.Doseresponse curves to CCK for amylase release shifted to the right with increase in Proglumide concentration.This inhibition by Proglumide is reversible.In addition,the effect of Proglumide is selective for CCK and its related peptide.The incubation of HT29 cells with Proglumide significantly reduces the [3H]-thymidine incorporation to HT29 cells in a dosedependent manner,with an IC50 of 6.5mM.Proglumide reduces in a dose-dependent manner the percentage of necrosis with a parallel increase of apoptosis up to 70%. 体内研究 Proglumide (250-750mg/kg;intraperitoneal injection;adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities,cognitive dysfunctions,and cerebral oxidative stress. Animal Model: Adult male Sprague Dawley rats (200-250g;2 months old) are induced status epilepticus (SE) Dosage: 250mg/kg,500mg/kg,and 750mg/kg Administration: Intraperitoneal injection Result: Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum.
保存条件：-20℃

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