生物试剂
>
生化试剂
>
信号通路
> KUL-7211 racemate
加入收藏 取消收藏

KUL-7211 racemate  

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：25mg 50mg 100mg in glass bottle
产品描述：基本信息 产品编号： K10116 产品名称： KUL-7211 racemate CAS: 911196-40-2   储存条件 粉末 -20℃ 四年 分子式： C19H23NO5 溶于液体 -80℃ 二年 分子量： 345.39     化学名：  2-[4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenoxy]acetic Acid Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 是 KUL-7211的外消旋体。KUL-7211 是一种选择性 β-肾上腺素受体激动剂。 靶点 β-adrenoceptor   体外研究 KUL-7211 is a new β-adrenoceptor agonist in vitro.In rat isolated organs,its selectivities,for inhibition of spontaneous uterine contraction (mediated via β2-adrenergic stimulation) and inhibition of colonic contraction (via β3-adrenergic stimulation) versus increase in atrial rate (via β1-adrenergic stimulation),are 56.3 and 242.2,respectively.KUL-7211 relaxes 80 mM KCl induced tonic contractions in both rabbit (pD2 value:5.86±0.13,whose ureteral relaxation is mediated via β2-adrenergic stimulation) and canine (pD2 value:6.52±0.16,via β3-adrenergic stimulation) isolated ureters in a concentrationdependent manner.These KUL-7211-induced relaxing effects are antagonized by ICI-118,551 (selective β2-adrenoceptor antagonist,pKB value: 8.91±0.24) in the rabbit ureter and by bupranolol (non-selective β-adernoceptor antagonist,pKB value:6.85±0.12) in the canine ureter.KUL-7211 also reduces the spontaneous rhythmic contraction in a canine ureteral spiral preparation in a concentration-dependent manner,the pD2 value being 6.83±0.20.These data clearly demonstrate that KUL-7211 selectively stimulates both ureteral β2- and β3-adrenoceptors and potently relaxes ureteral smooth muscle.
保存条件：-20℃

猜你喜欢