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异舒普林盐酸盐  ≥98%

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包装规格：1g in glass bottle
溶解性：溶于水（15.56mg/mL 超声），溶于DMSO（140mg/mL 超声）
产品描述：基本信息 产品编号： I10310 产品名称： Isoxsuprine hydrochloride CAS: 579-56-6   储存条件 粉末 -20℃ 四年     分子式： C18H23NO3.HCl 溶于液体 -80℃ 6个月 分子量： 337.84 -20℃ 1个月 化学名：  Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride Solubility (25°C)：   体外:   DMSO 68mg/mL (201.27mM) Ethanol 4mg/mL (11.83mM) Water 4mg/mL (11.83mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9600mL 14.7999mL 29.5998mL 5mM 0.5920mL 2.9600mL 5.9200mL 10mM 0.2960mL 1.4800mL 2.9600mL 50mM 0.0592mL 0.2960mL 0.5920mL   生物活性 产品描述 一种β 肾上腺素受体激动剂，对于子宫肌层和胎盘的 β 肾上腺素受体的 Ki 值分别为 13.65μM和3.48μM。Isoxsuprine hydrochloride 也是一种 NMDA 受体拮抗剂。 靶点 Ki:13.65μΜ (myometrial beta-adrenergic receptor),3.48μΜ (placcntal beta-adrenergic receptor) NMDA receptor   体外研究 Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60μM) and also inhibits 12(S)-HETE synthesis.Furthermore,Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2,MYPT and paxillin). 体内研究 Total infarct volume in vehicle-treated animals is 279±25mm3 compare to 137±18 mm3 in Isoxsuprine hydrochloride-treated animals.   推荐实验方法(仅供参考) 细胞实验:   MCF-7ALOX12 cells are seeded in 3.5-cm dishes and grown in 2.5mL complete MEM medium without selection pressure.The next day,the medium is changed to serum-free medium and cells are kept at 37℃ for 24h.Then,cells are treated with 10μM arachidonic acid and simultaneously with different concentrations of Isoxsuprine hydrochloride for 4h when the supernatants are aspirated,centrifuged at 2000,r.p.m.at 4℃ for 5 min,collected in cryo-tubes,flash frozen and stored at-80℃ until analysis.   动物实验:   Male spontaneously hypertensive rats (SHR) weighing 290 to 300g are used in this study.At reperfusion,animals receive 0.5mL of vehicle (0.6% DMSO in normal saline) or 1mg/kg Isoxsuprine hydrochloride by intravenous (IV) injection through the lateral tail vein.All animals receive 3mL of subcutaneous saline after surgery to prevent dehydration.After 24 hours reperfusion,animals are sacrificed,brains are sectioned into 4mm-thick quadrants,and infarcted tissue is identified by 2,3,5-triphenyltetrazolium chloride (TTC) staining.Edema-corrected infarct volume is calculated by subtracting the area of non-infarcted tissue in the ipsilateral hemisphere from the total volume of the contralateral hemisphere.Infarct volume is quantified using Image J software.
保存条件：-20℃

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