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LY 344864 hydrochloride  

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包装规格：50mg in glass bottle
产品描述：基本信息 产品编号： L10406 产品名称： LY 344864 hydrochloride CAS: 1217756-94-9   储存条件 粉末 -20℃ 四年     分子式： C21H22FN3O.HCl 溶于液体     分子量 387.88     化学名：  (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种选择性的 5-HT1F 激动剂，Ki 值为6nM。 靶点 5-HT1F Receptor 6nM (Ki) 体外研究 LY344864 is a selective receptor agonist with an affinity of 6nM (Ki ) at the recently cloned 5-HT1F receptor. It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolininduced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 is shown to be a full agonist producing an effect similar in magnitude to serotonin itself. 体内研究 After an intravenous dose of 1 mg/kg, rat plasma LY344864 levels decline with time whereas brain cortex levels remaine relatively constant for the first 6 hours after injection. Oral and intravenous LY344864 administration potently inhibit dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats. Co-injection of LY 344864 and systemically ineffective doses of METH significantly decreases preference scores and the rewarding properties of METH during the reinstatement phase. In addition, administration of LY 344864 has no effect on the acquisition of CPP in rats.   推荐实验方法(仅供参考) Animal Administration Rats Male albino Wistar rats are divided into different groups. Rats in the experimental LY344864 and sham groups receive LY 344864 (1 or 2μg/5μL; intracerebroventricular [i.c.v.]), vehicle (5μl/rat i.c.v.), or saline (5 μl/rat i.c.v.) during the acquisition phase
保存条件：-20℃

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