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Oxamflatin  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（50mg/mL超声）
产品描述：基本信息 产品编号：O10226 产品名称：Oxamflatin CAS: 151720-43-3   储存条件 粉末 -20℃ 四年     分子式： C17H14N2O4S 溶于液体 -80℃ 六个月 分子量 342.37 -20℃ 一个月 化学名：  (2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic Acid   Solubility (25°C)   体外 DMSO 50mg/mL (146.04mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9208mL 14.6041mL 29.2082mL 5mM 0.5842mL 2.9208mL 5.8416mL 10mM 0.2921mL 1.4604mL 2.9208mL   生物活性 产品描述 一种高效的 HDAC 抑制剂，IC50 值为15.7nM。 靶点/IC50 HDAC 15.7nM (IC50)   体外研究 Oxamflatin induces transcriptional activation of junD and morphological reversion in various NIH3T3-derived transformed cell lines. Oxamflatin shows antiproliferative activity against various mouse and human tumor cell lines with drastic changes in the cell morphology. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. Oxamflatin greatly enhances the transcriptional activity of the CMV promoter in a dosedependent manner and inhibits intracellular HDAC activity. Oxamflatin in the nanomolar range induces morphological changes in OVCAR-5 and SKOV-3 ovarian cancer cell lines.Treatment with oxamflatin also leads to decreased cell viability. Oxamflatin is able to significantly inhibit DNA synthesis and cell proliferation. Oxamflatin can induce E-cadherin expression and also reduce cell viability in the MKN-45 cell line.   体内研究 Injection of oxamflatin, six times at the dose of 20mg/kg, exhibits a significant increase in the days of survival (38% of ILS).The ILS of the mice treated with oxamflatin at the dose of 50mg/kg is calculated to be more than 67% and one mouse survived over 60 days after tumor inoculation. No subsidiary effect, such as body weight loss, is observed at least up to this dose.   推荐实验方法(仅供参考) 细胞实验： Cell Assay Cells grown in DMEM supplemented with 10% fetal bovine serum are challenged with serial two fold dilutions of oxamflatin on day 1 after the cells are seeded, and incubated for 2 days for the suspension cell cultures and for 3 days for the adherent cell cultures. Inhibition of the cell growth by oxamflatin is determined by staining with MTT as described previously.   动物实验:   Animal Administration Mice: Oxamflatin is injected intraperitoneally into BDF1 mice on day 1, 3, 5, 7, 9 and 11 and after the intraperitoneal inoculation of single cell suspension of the B16 melanoma cells. The survival days of the animals are recorded and the percent of increased life span (ILS%) is calculated.
保存条件：-20℃

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