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Etoposide phosphate disodium  

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包装规格：25mg 100mg in glass bottle
产品描述：基本信息 产品编号： E10357 产品名称： Etoposide phosphate disodium CAS: 122405-33-8   储存条件 粉末 -20℃ 四年     分子式： C29H31Na2O16P 溶于液体     分子量 712.50     化学名：  BMY-40481 disodium Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种有效的抗癌 (anti-cancer) 化疗试剂和一种选择性拓扑异构酶 II (topoisomerase II) 抑制剂，可以防止 DNA 链的重新连接。 靶点 Topoisomerase II     体外研究 Etoposide phosphate disodium is a water-soluble derivative and probable prodrug of etoposide characterized by the presence of a phosphate group in position 4' of the E ring of the etoposide molecule . Etoposide phosphate disodium (0-1μM; 72 hours) inhibits HCT116 FBXW+/+, FBXW-/- and p53-/- as a dose-dependent manner, exhibits IC50 values of 0.945μM; 0.375μM; and 1.437μM, respectively . Etoposide phosphate disodium (25μM; 6 hours) delays p53 recover in FBXW7-deficient cells. In addition, FBXW7 expression is disappeared in FBXW7-/- cells Cell Viability Assay   Cell Line: FBXW+/+, FBXW-/- and p53-/- cell Concentration: 0.025μM,0.05μM,0.075μM,0.1μM,0.2μM,0.4μM,0.6μM,0.8μM,1μM Incubation Time: 72 hours Result: Inhibited HCT116 FBXW+/+, FBXW-/- and p53-/- cell growth as a concentration manner.   Western Blot Analysis     Cell Line: HCT116 FBXW7+/+ or FBXW7-/- cells Concentration: 25μM Incubation Time: 6 hours Result: Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7. 体内研究 Etoposide phosphate (intravenous injection; 50, 100, or 150mg/kg; single dose) has clinical symptomology of progressiveataxia, impaired righting reflex, and splaying and paresis of fore- and hindlimbs at day 8 in female CD-1 mice   Animal Model: Female CD-1 mice Dosage: 50, 100, or 150mg/kg Administration: Intravenous injection; single dose Result: Observed degeneration of dorsal root ganglion cells and axonal degeneration of their distal and proximal processes in peripheral nerves, dorsal spinal roots, and dorsal funiculi of the spinal cord at all doses under light microscopy (LM).
保存条件：-20℃

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