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ZZW-115  

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产品描述：基本信息 产品编号：Z10038 产品名称：ZZW-115 CAS: 801991-87-7   储存条件 粉末 -20℃ 四年 分子式： C24H31F3N4S 溶于液体 -80℃ 两年 分子量 464.59     化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种有效的 NUPR1 抑制剂，Kd 为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。 靶点/IC50 Apoptosis 体外研究 ZZW-115 (0.1-33μM; 72 hours) is efficient in killing cancer cells, with an IC50 in the range of 0.84μM (ANOR) to 4.93μM (HN14).ZZW-115 (0-100μM; 24-72 hours) is efficient to kill these tumor cells with an IC50 in the range of 0.42μM (Hep2G cells) to 7.75μM (SaOS-2 cells).ZZW-115 induces pancreatic cell death by necrosis and apoptosis. ZZW-115 treatment induces a decrease in ATP production and induces a ROS overproduction.LDH release is significantly higher in ZZW-115-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner.Similarly, caspase 3/7 activity is also greater in ZZW-115-treated cells. These experiments demonstrated that ZZW-115 exerted both pronecrotic and proapoptotic effects.Cell Viability Assay Cell Line: ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration: 0.1- 33μM Incubation Time: 72 hours Result: Was efficient in killing cancer cells, with an IC50 in the range of 0.84μM (ANOR) to 4.93μM (HN14). Cell Proliferation Assay Cell Line: U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration: 0-100μM Incubation Time: 24 or 72 hours Result: Was efficient to kill these tumor cells with an IC50 in the range of 0.42μM (Hep2G cells) to 7.75μM (SaOS-2 cells). 体内研究 ZZW-115 (0.5-5mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors.ZZW-115 (5mg/kg for 30 days;immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases. Animal Model: NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells Dosage: 5, 2.5, 1.0, or 0.5mg/kg Administration: Injection, daily for 30 days Result: When the mice were injected with 5mg/kg ZZW-115, the tumors stopped growing a few days after treatment and their size decreased progressively,almost disappearing at the end of the treatment.
保存条件：-20℃

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