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去甲肾上腺素盐酸盐  ≥98%

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包装规格：100mg 250mg in glass bottle
溶解性：溶于DMSO（44 mg/mL 超声）
产品描述：基本信息 产品编号： N10647 产品名称： Norepinephrine hydrochloride CAS: 329-56-6   储存条件 粉末 2-8℃ 四年 分子式： C8H12ClNO3 溶于液体 -80℃(密封储存) 6个月 分子量： 205.64 -20℃(密封储存) 1个月 化学名：  BENZYL ALCOHOL,alpha-(AMINOMETHYL)-3,4-DIHYDROXY-,HYDROCHLORIDE,(-)- Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 4.8629mL 24.3143mL 48.6287mL 5mM 0.9726mL 4.8629mL 9.7257mL 10mM 0.4863mL 2.4314mL 4.8629mL   生物活性 产品描述 一种β1选择性的adrenergic receptor激动剂，EC50值为 5.37μM。 靶点 β1 adrenoceptor 5.37μM (EC50) Human Endogenous Metabolite   体外研究 Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist.Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations.Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured.To examine the effect of activating AT2 upon β-adrenergic signaling,cAMP production is first assessed in response to Norepinephrine (NE,10µM) with or without CGP (10nM) co-treatment.Norepinephrine (NE) increases cAMP as expected in iWA,and CGP does not alter this effect.Norepinephrine (NE) is also known to induce lipolysis,and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production.CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.   推荐实验方法(仅供参考) 细胞实验:   Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7.For the current studies,a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning.Cells are grown in preadipocyte PGM2 media.Once cells are confluent,differentiation is induced by incubation in differentiation media consisting of dexamethasone,IBMX,indomethacin,and additional insulin.Cells are differentiated for 10 days.Prior to treatment,media is replaced with PGM2 media for one day and then switched to serumfree media overnight for treatments. Adipocytes are treated for 6 hours with vehicle,Norepinephrine (NE,10μM),CGP (10nM),or Norepinephrine (NE) and CGP.
保存条件：2-8℃

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