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PB28  ≥98%

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包装规格：10mg 50mg in glass bottle
产品描述：基本信息 产品编号： P10705 产品名称： PB28 dihydrochloride CAS: 172906-90-0   储存条件 粉末 -20℃ 四年     分子式： C24H38N2O 溶于液体 -80℃ 6个月 分子量： 370.57 -20℃ 1个月 化学名：  1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种环己基哌嗪衍生物，是一种 Ki 值为 0.68nM 的高亲和力和选择性 sigma 2 (σ2) 受体激动剂。 靶点 Sigma Receptor Apoptosis SARS-CoV   体外研究 PB28 (15-25nM;24-48 hours;MCF7 and MCF7 ADR cells) dihydrochloride treatment shows an accumulation in the G0-G1 phase for MCF7 and MCF7 ADR cells that are time and concentration independent.PB28 dihydrochloride has a higher σ2 receptor affinity expressed as Ki (0.28nM and 0.17nM in MCF7 and MCF7 ADR cells,respectively) than σ1 receptor affinity (13.0nMand 10.0nM,respectively).PB28 dihydrochloride inhibits cell growth of MCF7 and MCF7 ADR cells with IC50s of 25nM and 15nM,respectively after 2-day treatment.PB28 dihydrochloride induces apoptosis through a caspase-independent pathway.PB28 dihydrochloride also reduces P-gp expression in a concentration- and time-dependent manner (approximately 60% in MCF7 and 90% in MCF7 ADR).PB28 dihydrochloride displays antiproliferative and cytotoxic effects in both C6 rat glioma and SK-N-SH human neuroblastoma cell lines. Cell Viability Assay Cell Line: MCF7 and MCF7 ADR cells Concentration: 25nM and 15nM Incubation Time: 24 hours,48 hours Result: Showed an accumulation in the G0-G1 phase for MCF7 and MCF7 ADR cells that were time and concentration independent. 体内研究 PB28 (10.7mg/mL;intraperitoneal injection;daily;for two weeks;C57BL/6 female mice) dihydrochloride treatment inhibits tumor growth in Panc02 tumor burden mice.PB28 also conferres a survival advantage for mice. Animal Model: C57BL/6 female mice (10 weeks old) injected with Panc02 cells Dosage: 10.7mg/mL Administration: Intraperitoneal injection;daily;for two weeks Result: Inhibited tumor growth in Panc02 tumor burden mice.
保存条件：-20℃

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