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Chloroquine dihydrochloride  

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产品描述：基本信息 产品编号：C10787 产品名称：Chloroquine dihydrochloride CAS: 3545-67-3   储存条件 粉末 2-8℃ 四年 分子式： C18H28Cl3N3 分子量 392.79 化学名：  n4-(7-chloroquinolin-4-yl)-n1,n1-diethylpentane-1,4-diamine dihydrochloride   Solubility (25°C)   体外 DMSO   Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine dihydrochloride 是autophagy 和toll-like receptors (TLRs) 的抑制剂。 靶点/IC50 HIV-1 Malaria TLRs SARS-COV-2   体外研究 Chloroquine dihydrochloride (20μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine dihydrochloride (20μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells. Chloroquine dihydrochloride (25μM)suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine dihydrochloride has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression. TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly reduces HuH7 cell proliferation in vitro.Chloroquine dihydrochloride (0.01-100μM; 48 hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV2) at low-micromolar concentration (EC50=1.13μM). Chloroquine dihydrochloride blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.   体内研究 Chloroquine dihydrochloride (80mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine.
保存条件：2-8℃

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