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HPi1  ≥98%

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包装规格：25mg 50mg 100mg 250mg in glass bottle
溶解性：溶于DMSO（62.5 mg/mL 超声)
产品描述：基本信息 产品编号：H10273 产品名称：HPi1 CAS: 13080-21-2   储存条件 粉末 -20℃ 四年 分子式： C8H8N4S 溶于液体 -80℃ 两年 分子量 192.24     化学名：  2(1H)-Quinoxalinone, 3,4-dihydro-3-thioxo-, hydrazone   Solubility (25°C)   体外 DMSO 60mg/mL (312.11mM Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 5.2018mL 26.0092mL 52.0183mL 5mM 1.0404mL 5.2018mL 10.4037mL 10mM 0.5202mL 2.6009mL 5.2018mL   生物活性 产品描述 一种针对幽门螺杆菌的有效，选择性和具有口服活性的抗菌剂，IC50 为 0.24μM，MIC 为 0.08-0.16μg/mL。 靶点/IC50 Helicobacter pylori IC50: 0.24μM Helicobacter pylori MIC: 0.08-0.16μg/mL   体外研究 The MIC against H. pylori isolates ranged from 0.002-0.032μg/mL (0.01-0.17μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016μg/mL) and ARHp246 (MIC of 0.008–0.032μg/mL).HPi1 has some activity against the Bacteroides species, but at concentrations at least 18-fold higher than the H. pylori MIC.More potent activity is detected for Campylobacter jejuni with an MIC of 0.3μg/mL.HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19μg/mL),human plasma protein binding (93% bound), stability with human liver microsomes (T1/2 of 1.3 hours) and the ability topassively permeate membranes.   体内研究 HPi1 (6.25-50mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50mg/kg/day. Animal Model: Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension Dosage: 6.25mg/kg, 12.5mg/kg, 25mg/kg, 50mg/kg Administration: Oral gavage; once a day; for 3 days Result: Oral gavage; once a day; for 3 days.
保存条件：-20℃

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