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L-4-噁溶菌素盐酸盐  ≥95%

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产品描述：基本信息 产品编号：O10182  产品名称：L-4-Oxalysine hydrochloride CAS: 118021-35-5   储存条件 粉末 -20℃ 四年     分子式： C5H13ClN2O3 溶于液体 -80℃ 六个月 分子量 184.62 -20℃ 一个月 化学名：  (S)-(+)-2-Amino-3-(2-aminoethoxy)propanoic acid monohydrochloride   Solubility (25°C)   体外 DMSO   Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。     生物活性 产品描述 从中国的链霉菌培养基中分离的天然物质，具有抗癌活性。 靶点/IC50 Fungal   体外研究 Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.   体内研究 Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stoppintreatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose. L-4- oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma     推荐实验方法(仅供参考) 动物实验:   Animal Administration Mice: Sixty mice are randomly and equally divided into 4 groups. One of the groups is given ig saline and the other are given ig 10, 50, 100mg /kg for 7d. On day l, 7, 14, and 28 respectively after terminating the treatment, 3 mice of each group are killed and the samples are examined under transmission electron microscope.
保存条件：-20℃

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