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KKL-35  ≥98%

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包装规格：2mg 5mg 10mg 25mg 100mg in glass bottle
溶解性：溶于DMSO（6.25 mg/mL 超声)
产品描述：基本信息 产品编号：K10072 产品名称：KKL-35 CAS: 865285-29-6   储存条件 粉末 -20℃ 四年     分子式： C15H9ClFN3O2 溶于液体 -80℃ 两年 分子量 317.70 -20℃ 一个月 化学名：  4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide   Solubility (25°C)   体外 DMSO 32mg/mL (100.72mM) Ethanol Insoluble Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.1476mL 15.7381mL 31.4762mL 5mM 0.6295mL 3.1476mL 6.2952mL 10mM 0.3148mL 1.5738mL 3.1476mL 50mM 0.0630mL 0.3148mL 0.6295mL   生物活性 产品描述 一种反式标记反应抑制剂，IC50值为0.9μM。 靶点/IC50 trans-translation tagging reaction IC50: 0.9µM   体外研究 KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 inhibit trans-translation at some step before proteolysis of tagged proteins. KKL-35 inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of KKL-35, indicating that KKL-35 does not inhibit translation. KKL-35 prevents growth of WT S. flexneri with a MIC of 6µM, and addition of KKL-35 to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of E. coli ∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM.     体内研究 Evidence suggest that the in vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require transtranslation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35.
保存条件：-20℃

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