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包装规格：10mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥ 30 mg/mL)
产品描述：基本信息 产品编号：T10582 产品名称：Terconazole CAS: 67915-31-5   储存条件 粉末 -20℃ 四年     分子式： C26H31Cl2N5O3 溶于液体 -80℃ 两年 分子量 532.46 -20℃ 一个月 化学名：  1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylpiperazine   Solubility (25°C)   体外 DMSO 49mg/mL (92.02mM) Ethanol 100mg/mL (187.8mM) Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8781mL 9.3904mL 18.7808mL 5mM 0.3756mL 1.8781mL 3.7562mL 10mM 0.1878mL 0.9390mL 1.8781mL 50mM 0.0376mL 0.1878mL 0.3756mL   生物活性 产品描述 一种用于研究阴道酵母菌感染的广谱抗真菌药物。 靶点/IC50 Fungal   体外研究 Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1μM terconazole through complete necrosis at 100μM. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL   体内研究 A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole.   推荐实验方法(仅供参考) 动物实验:   Animal Administration Rats: The rats are infected intravaginally with C. albicans. They are treated topically twice daily for 3 days, starting 24 hours after infection with a volume of 0.2 mL of various concentrations of terconazole (0.125%, 0.25%, 0.4%, 0.5%, 1%, 2%), miconazole, clotrimazole, econazole, nystatin, or amphotericin B.
保存条件：-20℃

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