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米托瓜酮  99.6568%

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包装规格：5mg 10mg 50mg in glass bottle
产品描述：基本信息 产品编号：M10651 产品名称：Mitoguazone CAS: 459-86-9   储存条件 粉末 2-8℃ 四年 分子式： C5H12N8 溶于液体 -80℃ 六个月 分子量 184.20 -20℃ 一个月 化学名：  2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine   Solubility (25°C)   体外 DMSO   Ethanol   Water 50mg/mL (271.44mM;ultrasonic and adjust pH to 9 with HCl) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 5.4289mL 27.1444mL 54.2888mL 5mM 1.0858mL 5.4289mL 10.8578mL 10mM 0.5429mL 2.7144mL 5.4289mL   生物活性 产品描述 一种具有有效抗肿瘤活性的合成多羰基衍生物。 靶点/IC50 HIV Apoptosis   体外研究 Mitoguazone competitively inhibits spermidine synthesis in lymphocytes at concentrations as low as 0.5μg/mL. Levels of 30μg/mL or more inhibit protein synthesis and mitochondrial respiration. The ability of Mitoguazone to induce apoptosis by inhibiting the polyamine pathway is assessed in three Burkitt's lymphomacell lines (Raji, Ramos and Daudi) and one prostate carcinoma cell line (MPC 3). Mitoguazone induces apoptosis in all thedifferent human cancer cell lines tested in a concentration- and time-dependent way, and triggers a p53-independentprogrammed cell death in the human breast cancer MCF7 cell line.   体内研究 The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in miceis investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reducedreflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stagethe drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-freecontrols in contrast to an earlier stage of leukemia.
保存条件：2-8℃

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