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盐酸妥布特罗  ≥98%

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包装规格：100mg 500mg in glass bottle
溶解性：溶于DMSO（50 mg/mL 超声)
产品描述：基本信息 产品编号： T0541  产品名称： Tulobuterol hydrochloride CAS: 56776-01-3   储存条件 粉末 -20℃ 四年     分子式： C12H19Cl2NO 溶于液体 -80℃ 6个月 分子量 264.19 -20℃ 1个月 化学名：  2-(tert-butylamino)-1-(2-chlorophenyl)ethanol;hydrochloride Solubility (25°C)：   体外:   DMSO 53mg/mL (200.61mM) Ethanol 10mg/mL (37.85mM) Water 53mg/mL (200.61mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.7852mL 18.9258mL 37.8515mL 5mM 0.7570mL 3.7852mL 7.5703mL 10mM 0.3785mL 1.8926mL 3.7852mL 50mM 0.0757mL 0.3785mL 0.7570mL   生物活性 产品描述 一种长效的 β2 肾上腺素受体激动剂，可减少慢性阻塞性肺疾病和支气管哮喘的发作频率。 靶点 β2-adrenoceptor   体外研究 Tulobuterol (0.1μM;24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection.The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection.Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells.Also reduces the RV14 infection-induced secretion of IL-1β,IL-6,and IL-8.Tulobuterol treatment produces a small but significant reduction in the amount of p50,p65,and c-Rel of NF-κB induced by RV14 infection. RT-PCR Cell Line: Human tracheal epithelial cells infected with RV14 Concentration: 0.1μM Incubation Time: 24 hours or 72 hours Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection.The concentrations of sICAM-1 in the supernatants of the cells were significantly lower.Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells.Also reduced the RV14 infection-induced secretion of IL-1β,IL-6,and IL-8.And produced a small but significant reduction in the amount of p50,p65,and c-Rel of NF-κB induced by RV14 infection. 体内研究 In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice;21.7±0.2g) treated with Endotoxin.Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E.coli endotoxin (20mg/kg) administration are measured.E0 and E4 diaphragm muscles are analyzed at 0,12,and 24h after transdermal Tulobuterol treatment.The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other,indicating that Tulobuterol patch restores the muscle contractility.Thus,diaphragm muscle contractility is maintained during 4h of endotoxin administration with Tulobuterol patch for over 24h.
保存条件：-20℃

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