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ST-193  ≥98%(HPLC)

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产品描述：基本信息 产品编号：S10414 产品名称：ST-193 CAS: 489416-12-8   储存条件 粉末 -20℃ 四年     分子式： C24H25N3O 溶于液体 -80℃ 六个月 分子量 371.47 -20℃ 一个月 化学名：  1-(4-methoxyphenyl)-N-[4-(propan-2-yl)benzyl]-1H-benzimidazol-5-amine   Solubility (25°C)   体外 DMSO 100mg/mL (269.20mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.6920mL 13.4600mL 26.9201mL 5mM 0.5384mL 2.6920mL 5.3840mL 10mM 0.2692mL 1.3460mL 2.6920mL   生物活性 产品描述 一种有效广谱的arenavirus抑制剂，抑制Guanarito、Junin、Lassa和Machupo病毒，IC50值分别为0.44、0.62、1.4和3.1nM。 靶点/IC50 Guanarito IC50: 0.44nM Junin 0.62nM Lassa 1.4nM Machupo 3.1nM   体外研究 ST-193 inhibits LASV pseudotypes with an IC50 of 1.6nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo,Guanarito, and Sabiá were in the 0.2 to 12nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10μM.   体内研究 ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8)and vehicle (0/7) groups.   推荐实验方法(仅供参考) 动物实验:   Animal Administration Guinea pigs: ST-193 is formulated as a solution in 32% (w/v) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Female Hartley guinea pigs are injected intraperitoneally with a 10mg/mL solution of ST-193 at a volume of either 2.5mL per kg of body weight (25 mg/kg) or 10mL per kg (100 mg/kg). Four animals per dose are used, with blood samples collected from two animals per dose at each time point in alternating fashion. Blood samples are obtained at the indicated time points (4-24 h)
保存条件：-20℃

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