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PRE-084 HCl 热销  ≥98%(HPLC)

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包装规格：50mg 250mg 1g in glass bottle
产品简介：一种高亲和力的选择性的sigma 1激动剂。
体外研究：PRE-084 (0.1-100 µM; 24 h) protects cultured cortical neurons against β-amyloid toxicity(maximally neuroprotective at 10 µM) and reduces the levels of proapoptotic protein Bax at 10µM.
体内研究：PRE-084 (0.25 mg/kg; i.p.; 3 times a week for 8 weeks) displays beneficial effects on motor performance (improves motor neuron survival, ameliorates paw abnormality and grip strength performance) in wobbler mice, and shows neuroprotective effects (increases the levels of BDNF in the gray matter). PRE-084 (1 mg/kg; i.p.; single) protects the heart by activating the Akt- eNOS pathway in myocardial infarction model.
细胞实验：Cell Line:Cortical cells (βAP(25-35)-induced neurotoxicity model) Concentration:0.1-100 µM Incubation Time:24 h Result:Reduced neuronal toxicity in a bell shaped-manner and is maximally neuroprotective at 10µM.
动物实验：Animal Model: Wobbler mice (4-week-old) Dosage:0.25 mg/kg Administration:Intraperitoneal injection; 3 times a week for 8 weeks. Result:Significantly improved ameliorated paw abnormality from week 4, and notably improved paw grip strength at week 5. Reduced the number of reactive astrocytes whereas increased the number of pan-macrophage marker CD68-positive cells and CD206+ cells involved in tissue restoration. Showed 26.5% increase in the mean number of large-size NISSL-positive motor neurons. Animal Model: Adult male Sprague‑Dawley rats (220-250 g; myocardial infarction model). Dosage:1 mg/kg Administration:Intraperitoneal injection; single. Result:Significantly decreased the degree of myocardial apoptosis. Led to significantly increased expression of p‑Akt and p‑eNOS.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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