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MPEP HCl  ≥98%(HPLC)

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(10mg/mL)
产品描述：基本信息 产品编号： M10327 产品名称： MPEP HCl CAS: 219911-35-0   储存条件 粉末 -20℃ 四年     分子式： C14H11N.HCl 溶于液体 -80℃ 6个月 分子量： 229.70 -20℃ 1个月 化学名：  2-METHYL-6-(PHENYLETHYNYL)PYRIDINE,HYDROCHLORIDE Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 4.3535mL 21.7675mL 43.5350mL 5mM 0.8707mL 4.3535mL 8.7070mL 10mM 0.4354mL 2.1768mL 4.3535mL   生物活性 产品描述 一种非竞争性mGlu5受体拮抗剂，IC50:36nM。 靶点 mGluR5 36nM (IC50) 体外研究 MPEP does not show agonist or antagonist activity at 100mM on human mGlu2,-3,-4a,-7b, and -8a receptors nor at 10μM on the human mGlu6 receptor. 体内研究 MPEP (1-30mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice.MPEP (1-20mg/kg) does shorten the immobility time in a tail suspension test in mice,however it is inactive in the behavioural despair test in rats.MPEP (30mg/kg i.p.) slightly but significantly increases (by 39%) the number of punished crossings in the four-plate test,lower doses of the compound (3 and 10mg/kg) does not affect the number of punished crossings in that test (F (3,36)=3.240,P<0.05).MPEP (1,10 and 20mg/kg) significantly (by 55% after the highest dose),(F(3,28)=15.47,P<0.001) decreases the immobility time of mice in the tail suspension test. Its efficacy is similar to that of imipramine (20mg/kg),used as the positive standard. Animal Model: Male Wistar rats (200±250 g). Dosage: IP or PO. Administration: 0.3,1 and 10mg/kg,i.p.(Conflict drinking test). Result: At a dose of 0.3mg/kg was not ffective,at doses of 1 and 10mg/kg i.p.significantly (F (3,30)=11.193,P<0.001),increased the number of shocks (by 330 and 507%,respectively) accepted during the experimental session in the Vogel test.   Animal Model: Male Wistar rats (200±250g). Dosage: IP or PO. Administration: 1,3 and 10mg/kg,i.p.or 10 and 30mg/kg,p.o.(Elevated plus-maze test). Result: Administered at a dose of 1mg kg71 i.p.did not change the entries into and time spent in the open arms.At doses of 3 and 10mg/kg i.p.significantly (F (3,24)=22.978,P<0.001) dosedependently increased the time spent in the open arms (up to 45 and 74%,respectively),and the percentage of entries into the open arms (up to 48 and 68%,respectively,F(3,24)=5.678,P<.01).At doses of 3 and 10mg/kg i.p.significantly increased (by 64%) the total number of entries and reduced (by about 25%) the total timespent (data not shown) in the arms (either type).At the dose of 30mg/kg (po,but not 10mg/kg) significantly (up to 64%, F (2,16)=14.249,P<0.001) increased the percentage of the time spent in the open arms and the percentage of entries into the open arms (up to 63%,F (2,16)=7.295,P<0.01).MPEP given p.o.in both doses used did not change the total number of entries nor the total time spent in the arms (either type).
保存条件：-20℃

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