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辛伐他汀 促销  ≥98% (HPLC)

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熔点：127-132°C
包装规格：1g 5g in poly bottle
溶解性：溶于DMSO(≥20mg/mL)
产品描述：一种具有抗增殖活性的HMGCR(HMG-CoA还原酶)抑制剂, IC50:3nM。 Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 μM)。
保存条件：2-8℃

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