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SR-31747 free base  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO(5mg/mL超声）
产品描述：基本信息 产品编号： S11211 产品名称： SR-31747 free base CAS: 132173-06-9   储存条件 粉末 -20℃ 四年 分子式： C23H34ClN 溶于液体 -80℃ 6个月 分子量 359.98 -20℃ 1个月 化学名：  3-(3-chloro-4-cyclohexylphenyl)-n-cyclohexyl-n-ethyl-2(z)-propenylamine Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7779mL 13.8897mL 27.7793mL 5mM 0.5556mL 2.7779mL 5.5559mL 10mM 0.2778mL 1.3890mL 2.7779mL   生物活性 产品描述 一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 free base 通过抑制固醇异构酶来阻止细胞增殖。 靶点 Sigma ligand   体外研究 SR-31747 blocks the proliferation of lymphocytes at a concentration of 10nM.SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24h after activation.SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. 体内研究 In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1,IL-6 and TNF-α in a dose-dependent manner (ED50,2mg/kg).SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids.This conclusion was supported by in vivo experiments that shows that:1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747;2) administration of SR-31747 induces an enhancement of the corticosterone level.SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.   推荐实验方法(仅供参考) 动物实验:   IL-1,IL-6 and TNF-a are induced by i.p.injection of LPS into BALBIc mice.SR 31747 or reference substances are administered i.p.at the indicated doses together with LPS (0.5mg/kg).Control animals are treated with LPS and vehicle.Blood samples are collected from the retro-orbital sinus 1hr or 4hr after LPS injection for the determination of TNF-α,IL-1 and IL-6. Plasma is prepared and stored frozen until experiments.The IL-1 plasma level is determined by a competitive radioreceptor assay with the use of the murine NOBEL4 cell line and [125I]-IL-1.The IL-6 assay is conducted with the B9 murine IL-6-dependent cell line.The TNF-a plasma level is evaluated by the cytolytic assay with the dactinomycin-treated LM6 cell line,derived from the murine fibroblastic L929 cell line.Each determination is performed on a pool of three different plasma samples.None of the molecules administered affect these assays even at the highest dose (10-5 M),which thereby rules out the possibility of any direct effect caused by the presence ofdrugs in treated-animal sera. In the various tests, one unit is defined as the amount of cytokines able to induce 50% of the maximal effect.
保存条件：-20℃

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