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JDTic dihydrochloride  ≥98%

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包装规格：1mg 5mg 10mg in glass bottle
溶解性：溶于DMSO(100mg/mL超声）
产品描述：基本信息 产品编号： J10084  产品名称： JDTic dihydrochloride CAS: 785835-79-2   储存条件 粉末 -20℃ 四年     分子式： C28H41Cl2N3O3 溶于液体 -80℃ 6个月 分子量： 538.55 -20℃ 1个月 化学名：  (3R)-7-Hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8568mL 9.2842mL 18.5684mL 5mM 0.3714mL 1.8568mL 3.7137mL 10mM 0.1857mL 0.9284mL 1.8568mL   生物活性 产品描述 一种有效的 kappa-opioid receptors (KOR) 的拮抗剂，常用于神经系统疾病的研究。 靶点 Opioid Receptor 体内研究 JDTic (2.5-16mg/kg,s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine.JDTic (3mg/kg,i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety.JDTic (10mg/kg,i.p.) decreases alcohol self-administration,suppresses cue-induced reinstatement of alcohol seeking,and specifically blocks the effects of a KOR agonist at the 2h pretreatment time point.JDTic (30mg/kg,i.g.) significantly blockes U50,488-induced diuresis immediately in rats.     推荐实验方法(仅供参考) 动物实验:   Mice:Naive mice are injected s.c.with JDTic (1,4,8,or 16mg/kg) 18h prior to nicotine (2.5mg/kg,s.c.).Due to JDTic’s very long duration of action,an 18-h preinjection is chosen for the studies.Antinociception using the tail-flick and hot-plate tests is measured 5 min after nicotine injection or 20 min after morphine (8mg/kg,s.c.),and changes in body temperature are measured 30 min after injection.To confirm an absence of mu antagonist effects by JDTic in these studies,JDTic (16mg/kg) is also administered 1,6,18,and 24h before morphine (8 mg/kg,s.c.) in the tail-flick test,and antinociception is measured 20 min after morphine.
保存条件：-20℃

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