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Saredutant  ≥98%

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包装规格：1mg 5mg 10mg in glass bottle
溶解性：溶于DMSO(250mg/mL超声）
产品描述：基本信息 产品编号： S80006 产品名称： Saredutant CAS: 142001-63-6   储存条件 粉末 -20℃ 四年     分子式： C31H35Cl2N3O2 溶于液体 -80℃ 6个月 分子量 552.53 -20℃ 1个月 化学名：  (S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8099mL 9.0493mL 18.0986mL 5mM 0.3620mL 1.8099mL 3.6197mL 10mM 0.1810mL 0.9049mL 1.8099mL   生物活性 产品描述 一种选择性 NK2 受体拮抗剂。 靶点 NK2   体内研究 Saredutant,an NK2 receptor antagonist,has both antidepressant-like effects and synergizes with desipramine in an animal model of depression.Saredutant has dose-dependent effects on swim test immobility,with the low dose of 1mg/kg having no effect and the doses of 3 and 10mg/kg significantly reducing immobility.   推荐实验方法(仅供参考) 动物实验:   Rats In the first experiment the dose-related effects of Saredutant are investigated.The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following:vehicle (carboxymethylcellulose-CMC) or 1,3,or 10mg/kg Saredutant,or 5mg/kg Desipramine as a positive control.Saredutant is injected at 1mL/kg.The Flinders Resistant Line (FRL) rats are given CMC or 3mg/kg Saredutant.All injections are i.p.and are given for 14 consecutive days.Approximately 22h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording.Then about 2h later the rats are individually tested in the forced swim test for a single 5-min session.
保存条件：-20℃

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