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依鲁替尼-生物素  ≥98%

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包装规格：1mg 5mg in glass bottle
溶解性：溶于DMSO（50mg/mL超声）
产品描述：基本信息 产品编号：I10417 产品名称：Ibrutinib-biotin CAS: 1599432-18-4   储存条件 粉末 -20℃ 四年     分子式： C56H80N12O9S 溶于液体 -80℃ 六个月 分子量 1097.37 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 0.9113mL 4.5563mL 9.1127mL 5mM 0.1823mL 0.9113mL 1.8225mL 10mM 0.0911mL 0.4556mL 0.9113mL   生物活性 产品描述 一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针，具体可参考 WO2014059368A1 中 Compound 1-5，抑制 BTK，IC50 值为 0.755-1.02nM。 靶点/IC50 IC50:0.755-1.02nM (BTK),1.71-2.29nM (TEC),3.66-4.27nM (BLK), 4.42-5.57nM (BMX), 5.99-6.92nM (LCK), 33.8-36.3nM (Src), 0.187-0.198μM (ITK),5.34-4.87μM (JAK3)   体外研究 Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosinemediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells.   推荐实验方法(仅供参考) 激酶实验： In this study, assay formats are tested for sensitivity, specificity, range, and to determine most suitable anti BTK Antibody.An aliquot of DOHH2 cell lysate (1mg/mL) is inhibited with 1μM Ibrutinib then labeled with probe (1μM). Negative controls: Untreated DOHH2 and Jurkat cell lysates (lmg/mL) are labeled with probe (1μM) and Untreated DOHH2 cell lysate.Standard Streptavidin plate (5-pack); Read Buffer T (50mL), SULFO TAG Goat Anti-mouse (50μg); SULFO TAG Goat Antirabbit (50μg); SULFO TAG streptavidin (50ug); MSD Standard Plates; MSD Blocker A; Protease inhibitor cocktail; Positive Control lysates from BTK expressing cell line (DOHH2); Negative Control lysates; Ibrutinib (PCI); probe compound 1-5 (biotinylated probe).
保存条件：-20℃

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