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Marimastat  ≥98%

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包装规格：25mg 100mg in glass bottle
溶解性：溶于DMSO(＞20mg/mL)
产品描述：一种广谱的，具有口服活性的 MMPs 抑制剂,一种血管生成和转移抑制剂，用于癌症的研究。限制血管的生长和生成。作为一种抗变形剂，Marimastat (BB2516) 可以防止恶性细胞突破基底膜。Marimastat, aslo known as BB-2516 and TA-2516, is an orally-active synthetic hydroxamate and inhibitor of matrix metalloproteinases with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis.
保存条件：-20℃

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