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TRPC6-IN-1  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(100mg/ml超声)
产品描述：基本信息 产品编号： T11147 产品名称： TRPC6-IN-1 CAS: 901715-05-7   储存条件 粉末 -20℃ 四年     分子式： C21H23FN4O3 溶于液体 -80℃ 6个月 分子量： 398.43 -20℃ 1个月 化学名：  4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl ester Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.5099mL 12.5493mL 25.0985mL 5mM 0.5020mL 2.5099mL 5.0197mL 10mM 0.2510mL 1.2549mL 2.5099mL 生物活性 产品描述 一种TRPC6的抑制剂。 靶点 EC50:0.45μM (TRPC3),1.13μM (TRPC7),4.66μM(TRPC3).   体外研究 TRPC6-IN-1 (compound 4o) rises in the TRPC6 cells in a concentration dependent manner,with a mean EC50 value of 4.66±0.03μM,demonstrating a comparable activity of the compound on TRPC6 as the original lead.TRPC6-IN-1 is also tested on HEK293 cells that co-expressed μ opioid receptor (MOR) and TRPC4β,which belongs to a different subgroup of TRPC channels than TRPC3/6/7.Upon stimulation by a μ agonist,these cells show a robust increase in [Ca2+]i.TRPC6-IN-1 also evokes whole-cell currents in HEK293 cells that express human TRPC3.TRPC6-IN-1 elicits concentration dependent current increases in the TRPC7 cells.Different from TRPC6,the currents show some desensitization in the high TRPC6-IN-1 concentrations (10 and 30μM) at both negative and positive potentials even though the low Ca2+(0.1mM) bath solution is used.Nonetheless,a stepwise increase in the TRPC7 currents is still detected at <10μM TRPC6-IN-1.
保存条件：-20℃

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