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JZP-430  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(100mg/ml超声)
产品描述：一种有效的、高度选择性的、不可逆的α/β水解酶结构域6(ABHD6)抑制剂，靶向抑制人类ABHD6的IC50值为44nM。JZP-430 is a potent and selective ABHD6 inhibitor. P-430 potently and irreversibly inhibited hABHD6 (IC50 =44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.
保存条件：-20℃

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