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LXR-623  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(20mg/ml)
产品描述：一种可以渗透血脑屏障的LXRα部分激动剂和LXRβ完全激动剂LXR623, also known as WAY-252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR(-/-) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significantly reduced total (50-55%) and LDL-cholesterol (LDLc) (70-77%) in a time- and dose-dependent manner as well as increased expression of the target genes ABCA1/G1 in peripheral blood cells.
保存条件：-20℃

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