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SN2  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(100mg/mL 超声)
产品描述：基本信息 产品编号： S10990  产品名称： SN2 CAS: 823218-99-1   储存条件 粉末 -20℃ 四年     分子式： C17H21NO 溶于液体 -80℃ 6个月 分子量： 255.35 -20℃ 1个月 化学名：  3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole Solubility (25°C)：   体外:   DMSO   Ethanol   Water I 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.9162mL 19.5810mL 39.1619mL 5mM 0.7832mL 3.9162mL 7.8324mL 10mM 0.3916mL 1.9581mL 3.9162mL 生物活性 产品描述 一种有效的TRPML3离子通道激活剂。 靶点 EC50:1.8±0.13μM (TRPML3),>29.9μM (TRPML1)   体外研究 The conductance of TRPML3 channels is estimate, when activated with 10µM SN-2 is approximately 10pS at −80mV.TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS),with compound in ELS,and finally with ELS alone.Two representative compounds,SF-24 and SN-2,are tested.SF-24 is one of the least effective compounds,and SN-2 is one of the most active ones.SN-2 has a similar synergistic effect,also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses,reaching average current densities of up to 3nA/pF at −80mV.Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes,suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K).Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.
保存条件：-20℃

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