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CP-532623  ≥98%

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： C70135 产品名称： CP-532623 CAS: 261947-38-0   储存条件 粉末 -20℃ 四年     分子式： C27H27F9N2O3 溶于液体 -80℃ 六个月 分子量 598.50 -20℃ 一个月 化学名：  (2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester   生物活性 产品描述 CETP抑制剂，可提高高密度脂蛋白胆固醇水平。CP-532623与Torcetrapib的结构相似，并具有高度亲脂性。 靶点 CETP 体外研究 CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons 体内研究 CP-532623 (50mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623 Animal Model: Adult male greyhound dogs (27-39kg) Dosage: 50mg Administration: Oral administration with a long-chain lipid formulation to fed lymphcannulated Result: Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph.
保存条件：-20℃

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