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Iganidipine  

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包装规格：1mg 5mg in glass bottle
产品描述：基本信息 产品编号： I10349 产品名称： Iganidipine CAS: 119687-33-1   储存条件 粉末 -20℃ 四年 分子式： C28H38N4O6 溶于液体 -80℃ 一年 分子量： 526.62     化学名：  5-O-[2,2-dimethyl-3-(4-prop-2-enylpiperazin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种钙离子通道拮抗剂。 靶点 Ca2+ 体内研究 Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NBONH) by 8 to 10% in treated eyes after a single administration (p<0.05) or by 18 to 35% after 7-,14-,or 21-day twicedaily administration in rabbits (p<0.05).In monkeys,0.03% and 0.1% Iganidipine significantly increases NBONH in treated eyes by 20 and 41% after 7-day (p<0.05)twice-daily administration,respectively.   推荐实验方法(仅供参考) 动物实验:   Monkeys Five adult cynomolgus monkeys (age,5-8 years;weight,3-5kg;sex,5 males) are used.All examinations are performed with the monkeys sitting in a modified monkey chair.On the first experimental day,after general anesthesia is induced by Ketamine hydrochloride at a dose of 8 to 10mg/kg intramuscularly,pupil dilation is induced with one drop of Tropicamide in both eyes.The NBONH,IOP,blood pressure,pulse rate,SaO2,and body temperature are measured at 9AM.Starting on the 2nd experimental day,Iganidipine (0.03% or 0.1%,30mL) is administered in one randomly chosen eye and vehicle solution into the other eye twice daily at 8AM and 8PM for 7 days.At 9AM on the 8th experimental day,the same measurements are repeated after general anesthesia and bilateral pupil dilation.After a 4-week interval,a second series of experiments is performed using a different Iganidipine concentration according to the same time schedule.
保存条件：-20℃

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