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包装规格：1mg 5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO（100mg/mL 超声）
产品描述：基本信息 产品编号： P11019  产品名称： Pentiapine CAS: 81382-51-6   储存条件 粉末 -20℃ 四年 分子式： C15H17N5S 溶于液体 -80℃（避光） 6个月 分子量： 299.39 -20℃（避光） 1个月 化学名：  5-(4-methylpiperazin-1-yl)imidazo[2,1-b][1,3,5]benzothiadiazepine Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.3401mL 16.7006mL 33.4012mL 5mM 0.6680mL 3.3401mL 6.6802mL 10mM 0.3340mL 1.6701mL 3.3401mL   生物活性 产品描述 一种多巴胺释放 (dopamine release) 抑制剂，不与突触多巴胺受体位点结合。 靶点 Dopamine receptor  体内研究 Pentiapine is a novel dopamine release inhibitor.The results show that Pentiapine dose-dependently reduces motor activity of mice.Moreover,Pentiapine dose-dependently reduces morphine-induced hyperactivity.Newman-Keuls post-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groups receiving morphine plus 2 (P<0.05),4,8,16,24 and 32 (P<0.01)mg/kg of Pentiapine.Moreover,the groups receiving morphine plus 0.5,1 and 2mg/kg of Pentiapine present more activity than the groups receiving morphine plus 4,8,16,24 and 32mg/kg of Pentiapine (P<0.01).30mg/kg dose of Pentiapine completely blocks the methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment of a cocaine CPP.   推荐实验方法(仅供参考) 动物实验:   Two hundred and fifty-seven male mice are used in this study.Animals are divided into 19 groups (n=8).The first group receives physiological saline,the second receives 40mg/kg of morphine and the other eight groups receive 0.5,1,2,4,8,16,24 or 32mg/kg of Pentiapine,respectively.The remaining groups receive an injection of morphine and 30 min afterwards,an injection of physiological saline,0.5,1,2,4,8,16,24 or 32mg/kg of Pentiapine,respectively.In the groups receiving only one injection,animals are placed onto the sensory plates for a period of 90 min immediately after treatment.The computer registers the activity each 15 min.In the groups receiving two injections,animals are placed onto the sensory plates immediately after the first injection for a period of 30 min then after the second injection the motor activity is registered at 15,30,45 and 60 min.
保存条件：-20℃

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