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Small Cardioactive Peptide B SCPB  ≥99%

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包装规格：1mg 5mg 10mg in glass bottle
产品描述：基本信息 产品编号： S10834  产品名称： Small Cardioactive Peptide B SCPB CAS: 84746-43-0   储存条件 粉末 -20℃ 四年     分子式： C52H80N14O11S2 溶于液体 -80℃(避光，储存于氮) 6个月 分子量： 1141.41 -20℃(避光，储存于氮) 1个月 化学名：  MET-ASN--LEU-ALA-PHE-PRO-ARG-MET (MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE) Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 0.8761mL 4.3805mL 8.7611mL 5mM 0.1752mL 0.8761mL 1.7522mL 10mM 0.0876mL 0.4381mL 0.8761mL   生物活性 产品描述 一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0μM。 靶点 0.1μM (adenylate cyclase, in heart tissues),1.0μM (adenylate cyclase, in gill tissues)   体外研究 Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia.Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined.In addition,the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues,respectively.Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent,reversible changes in cardiac activity when perfused through the isolated heart.The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3nM,respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1pM,respectively. When perfused through the isolated gill,Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01pM and an EC50 value of 0.03nM.Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly.Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM,respectively.
保存条件：-20℃

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