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Sulamserod  

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包装规格：100mg in glass bottle
产品描述：基本信息 产品编号： S10830 产品名称： Sulamserod CAS: 219757-90-1   储存条件 粉末 -20℃ 四年     分子式： C19H28ClN3O5S 溶于液体     分子量 445.96     化学名：  N-[2-[4-[3-(5-amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 生物活性 产品描述 一种 5-HT4 receptor 拮抗剂，具有抗心律失常的功效。 靶点 5-HT4 Receptor 体内研究 Sulamserod (30 mg/kg) prolongs mean ERP (11568 versus 14667 ms, P,0.01) and wavelength (8.360.9 versus 9.960.8 cm, P,0.01), reduces dispersion of ERP (1565 versus 861 ms, P,0.01), and minimally slows conduction velocity (7264 versus 6765 cm/s, P,0.01) in pigs. Sulamserod produces no ventricular electrophysiological effects. Sulamserod terminates atrial flutter in 6 of 8 animals and atrial fibrillation in 8 of 9 animals and prevents reinduction of sustained tachycardia in all animals. 推荐实验方法(仅供参考) Animal Administration After completion of baseline electrophysiological measurements and induction of sustained AFL or AF, the 5-HT4 receptor antagonist RS-100302 is administered in a dose of 30μg/kg over 10 minutes. This dose of RS-100302 is previously determined to maximally inhibit 5-HT-induced tachycardia in pigs. After completion of drug infusion, each animal is monitored for 20 minutes to observe arrhythmia response. If AFL or AF does not terminate spontaneously within 20 minutes after completion of drug infusion, sinus rhythm is restored by burst pacing or DC cardioversion, respectively. Electrophysiological measurements are then repeated as during control, and a venous blood sample is drawn for plasma levels of RS-100302. Attempts are then made to reinduce AFL or AF as performed at control. Reinduced arrhythmias are defined as sustained if lasting >10 minutes, nonsustained if lasting >30 seconds but
保存条件：-20℃

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