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ST 2825  ≥98%

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包装规格：1mg in glass bottle
溶解性：溶于DMSO（100 mg/mL超声） -20°C
产品描述：基本信息 产品编号： S10906 产品名称： ST 2825 CAS: 894787-30-5   储存条件 粉末 -20℃ 四年     分子式： C27H28Cl2N4O5S 溶于液体 -80℃ 6个月 分子量： 591.51 -20℃ 1个月 化学名：  (2R,4'R,8a'R)-1-(2-(4-(2-(2,4-dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.6906mL 8.4529mL 16.9059mL 5mM 0.3381mL 1.6906mL 3.3812mL 10mM 0.1691mL 0.8453mL 1.6906mL   生物活性 产品描述 一种特异的MyD88二聚化抑制剂。 靶点 MyD88   体外研究 ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization.ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at 5μM ST2825 and 80% inhibition at 10μM ST2825. 体内研究 ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration.The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200mg/kg,5 min prior to i.p.injection with 20μg/kg IL-1β.ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200mg/kg.   推荐实验方法(仅供参考) 细胞实验:   HeLa cells are seeded at 105 cells/mL in a 96-well tissue-culture plate.After incubating overnight,the medium is discarded,and the cells are added with tissue culture medium,10% FBS,containing ST2825 at concentrations ranging from 0.1 to 10μM and DMSO at 0.1% final concentration.The cells are incubated for 6 and 18h and then added with the yellow XTT (0.3mg/mL) for further 2h of incubation.At the end of the incubation periods,reactions are quantified by using a Sirio S Seac microplate reader.   动物实验:   Mice Mice (female C57Bl/6) are divided into experimental groups of 15 mice.They are injected i.p.with saline (control animals) or recombinant murine IL-1β (20μg/kg).A time-course analysis of IL-6 production established that the peak of cytokine is reached 2h after IL-1β injection.ST2825,administered orally as 0.5% suspension in carboxymethylcellulose (CMC) or CMC alone,is supplied to the experimental mice groups.Two hours after IL-1β injection,the animals are killed,and sera are collected to assay IL-6 levels.Mice,which are treated orally with 100 and 200mg/kg ST2825,shows lower levels of IL-6 versus CMC-treated mice.
保存条件：-20℃

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