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Datelliptium chloride  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于水（41.67mg/mL 超声），溶于DMSO（5mg/mL 超声）
产品描述：基本信息 产品编号：D10815 产品名称：Datelliptium chloride CAS: 105118-14-7   储存条件 粉末 -20℃ 四年     分子式： C23H28ClN3O 溶于液体 -80℃ 六个月 分子量 397.94 -20℃ 一个月 化学名：  2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium chloride   Solubility (25°C)   体外 DMSO 5mg/mL (12.56mM; Need ultrasonic) Ethanol   Water 40mg/mL (100.52mM; Need ultrasonic 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.5129mL 12.5647mL 25.1294mL 5mM 0.5026mL 2.5129mL 5.0259mL 10mM 0.2513mL 1.2565mL 2.5129mL   生物活性 产品描述 一种源于 ellipticine 的 DNA 嵌合剂，具有抗肿瘤活性。 靶点/IC50 DNA/RNA Synthesis 体外研究 Datelliptium (100μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate. 体内研究 Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170mg/kg TD, and weight loss of 10%, T/C of 0%.   推荐实验方法(仅供参考) 细胞实验： Cell Assay Cytotoxicity is estimated after short-term exposure (2 hr) to datelliptium using suspended and cultured rat hepatocytes. When cytotoxicity is evaluated after longer-term exposure, using human and rat monolayers and hepatoma cell lines, the compound is added 1 hr after cell plating and incubated for 23 hr. The loss of intracellular LDH and the MTT test are the endpoints evaluated in cultured cells. The intracellular LDH is measured in the microwell culture plates by a colorimetric method. The MTT test, reduction of the tetrazolium salt MTT to formazan by mitochondrial succinate dehydrogenase, is performed as described. Cytotoxicity in the hepatocyte suspension is evaluated by LDH leakage to the medium after a 2-hr treatment with the drug.
保存条件：-20℃

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