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GC7 Sulfate  99.68%

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包装规格：1mg 5mg 10mg 25mg 100mg in glass bottle
溶解性：溶于水（3 mg/mL 超声，加热）
产品描述：基本信息 产品编号：G10399 产品名称：GC7 Sulfate CAS: 150417-90-6   储存条件 粉末 -20℃ 四年     分子式： C8H22N4O4S 溶于液体 -80℃ 两年 分子量 270.35 -20℃ 一个月 化学名：  2-(7-aminoheptyl)guanidine;sulfuric acid   Solubility (25°C)   体外 DMSO Insoluble Ethanol Insoluble Water 3mg/mL (11.09mM) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.6989mL 18.4945mL 36.9891mL 5mM 0.7398mL 3.6989mL 7.3978mL 10mM 0.3699mL 1.8495mL 3.6989mL   生物活性 产品描述 一种脱氧嘌呤合成酶 (DHPS) 抑制剂。 靶点/IC50 DHPS ()   体外研究 The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein[1]. Between 0 and 20μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20μM GC7 Sulfate treatment, compare to untreated control. The activity of [3H]-spermidine incorporated into HCC cells is significantly decreased by 20μM GC7 Sulfate or higher concentration.     推荐实验方法(仅供参考) 细胞实验： Cell Assay Cell viability is analyzed with the MTS assay kit in accordance with the manufacturer’s protocols. Briefly, after treatment with GC7 Sulfate for 72 h at various concentrations (0.1 to 100μM) in 96-well plates, cells are directly incubated with the MTS dye reagent for 1 h at 37°C in a 5 % CO2 atmosphere. The absorbance is read at 490nm using a reader .
保存条件：-20℃

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